The acute phase of myocardial necrosis induced by isoproterenol mimics changes in blood pressure, heart rate, electrocardiogram ecg, and left ventricular dysfunction similar to that occurring in patients with myocardial infarction. Effect of gonadectomy on isoproterenolinduced myocardial. Cardioprotective effects of puerarinv on isoproterenol. Clinical guidelines distinguish between myocardial injury and myocardial infarction mi. Henceforth, in the present study, myocardial ischemia mi was created in wistar rats using isoproterenol iso, a wellestablished model for investigating mi. Trakya university institute of health sciences, master thesis in department of medical biochemistry, edirne, turkey. Artile investigation of the protective effect of kefir. Curcumin has antiinflammatory, antioxidative, anticarcinogenic, and cardiovascular protective effects. The effect of astragaloside iv on isoproterenol induced myocardial infarction in rats article pdf available in pharmaceutical sciences 252. The rat model of isoproterenol induced myocardial infarction offers. Effect of kefir against isoproterenol induced myocardial infarction in rats 269 gutteridge jm.
Blood and tissue samples liver, brain, adrenal glands, normal and necrotic areas of the heart were collected 15, 30, and 45 minutes after tracer injection. Adult male and female spraguedawley rats were subjected to an isopro terenol induced myocardial infarction. Protective effect of taurine on myocardial antioxidant status. Cc on isoproterenol iso induced myocardial infarction mi in rats. Six weeks before the induction of myo cardial infarction, some of the animals had been orchiectomized or ovari ectomized. The animals were autopsied at regularly timed intervals on days 1, 2, 3, 8, and 15 after myocardial infarction. Mature male rats with isoproterenol induced myocardial infarction and normal controls were injected intravenously with 1, 23 h corticosterone 3 h corticosterone. Introduction myocardial infarction mi is an important cause of mortality around the world, resulting. Curcumin from curcuma longa is a nutraceutical compound reported to possess strong antioxidant activity that makes it a candidate for use in counteracting oxidative stress induced damage. The effect of astragaloside iv on isoproterenolinduced myocardial infarction in rats article pdf available in pharmaceutical sciences 252.
Europium hydroxide nanorods ehns ameliorate isoproterenol. Two hundred mgkg iso dose was selected for the present study as this dose offered significant. The rats were subcutaneously injected with isoproterenol iso 85 mgkg at an interval of 24 hours for two days. Fifty wistar strain male albino rats, weighing 200 10, were selected for the study. Experimental model of myocardial infarction induced by. Madhesh murugesan, ramalingam revathi, and vaiyapuri manju. Pdf evaluation of cardioprotective role of vinpocetine. Pdf isoproterenolinduced myocardial infarction in wistar rats. Isoproterenolinduced myocardial infarction in rats. Cardioprotective effect of fenugreek on isoproterenolinduced myocardial infarction in rats. Sixty rats were randomly divided into six groups of 10 rats each. In the present study, we report that wogonin nanoparticles wog np protect isoproterenol iso induced myocardial infarction mi rats.
Nov 23, 2017 sequential changes of energy metabolism and mitochondrial function in myocardial infarction induced by isoproterenol in rats. Vinpocetine is a phosphodiesterase type1 inhibitor having strong vasodilating effect through camp and cgmp elevation. In addition to its antiviral effect, ritonavir directly inhibits the insulinregulated glucose transporter glut4 and blocks glucose entry into fat and muscle cells. Cardioprotective effect of fenugreek on isoproterenolinduced. Possible effect of natural honey on isoproterenol induced acute myocardial infarction in adult male albino rats marwa a omar, fatma elnabawia, a elsafty, wael b elkholy and abeer e elmehi department anatomy and embryology, faculty of medicine, menoufia university, menoufia, egypt submission. The activities of creatine kinase on myocardial bundle ckmb and lactate dehydrogenase ldh were also reduced. Original article baicalin ameliorates isoproterenolinduced. Pdf the effect of astragaloside iv on isoproterenol. Origination and development of isoproterenolinduced myocardial infarction in male wistar rats. Protective effect of scutellarin on myocardial infarction induced by. Jan 04, 2007 we studied the cardioprotective effect of squalene on isoprenaline induced myocardial infarction in male albino rats with respect to changes in the levels of lipid components in plasma and heart ti. Article pdf available in international research journal of.
Ginsenoside re attenuates isoproterenolinduced myocardial. Polyphenol was extracted from cocoa using a hydroalcohol solvent. For this,tamoxifen was administered to spraguedawley rats for 114 days, and isoproterenol iso 100 mgkg body mass. Curcumin and curcumin nanoparticles were given by gavage in three di. Exercise training, indomethacin, and isoproterenolinduced. Wistar male albino rats were randomly divided and treated with extract of cardamom 100 and 200 mgkg per oral or normal saline for 30 days with concomitant administration of iso 85 mgkg, subcutaneous on 29th and 30th days, at 24 h interval. Male wistar rats were orally given ginsenoside re 5, 20 mgkg daily for 7 days. Possible effect of natural honey on isoproterenol induced.
Our study is aimed at evaluating the effects of pretreatment with curcumin nanoparticles ccnp compared to conventional curcumin cc on isoproterenol iso induced myocardial infarction mi in rats. Alprazolam decreases isoproterenol induced myocardial damage. Myocardial infarction induced by isoproterenol iso. The present study was designed to investigate the cardioprotective effects of sundarban honey sh in rats with isoproterenol iso induced myocardial infarction. Dec 14, 2018 however, the cardioprotective effects of puerarinv on myocardial infarction mi heart failure are still unclear. Fiftysix wistarbratislava white rats were randomly divided into eight groups of seven rats each. However, the cardioprotective effects of puerarinv on myocardial infarction mi heart failure are still unclear.
Pdf origination and development of isoproterenolinduced. Myocardial trauma and damage were induced by two doses of isoproterenol 40 mgkg. A tool for inducing myocardial infarction in experimental animals, authormohd aftab siddiqui and usama sharif ahmad and ahmed abdullah khan and mohammad ayaz ahmad and badruddeen and mohammad khalid and juber akhtar, year2016. Jan 23, 2017 the animal model of iso induced myocardial injury recapitulates major metabolic and morphological changes that occur during human myocardial infarction, thus being widely adopted as an. Isoproterenolinduced myocardial infarction in rabbits. Mature male rats with isoproterenolinduced myocardial infarction and normal controls were injected intravenously with 1, 23h corticosterone 3h corticosterone. In this research, we aim to evaluate the cardioprotective effects of puerarinv on the isoproterenol iso induced mi mice and elucidate the underlying mechanisms. Beneficial role of tamoxifen in isoproterenolinduced. The protective impact of betaine on the tissue structure and. Original article baicalin ameliorates isoproterenol induced acute myocardial infarction through inos, inflammation, oxidative stress and p38mapk pathway in rat shenjie sun, xiaopeng wu, hengliang song, guiqi li department of cardiology, the second hospital affiliated to zhengzhou university, zhengzhou 450014, henan, china. Protective effects of cardamom in isoproterenolinduced. Myocardial infarction induced by isoproterenol iso using toxic concentration of this. Lipid peroxidation and antioxidants as biomarkers of tissue damage. Preventive effect of esculetin on lipid peroxides and.
The protective effect of scu on isoinduced mi was evaluated by measuring markers of. Diabetes and isoproterenol induced myocardial infarction was evident as a reduction in maximal positive and negative rate of developed left ventricular pressure and an increase in left ventricular enddiastolic pressure. A biochemical, electrocardiographic and histoarchitectural evaluation. Sham group, which underwent a virtual myocardial infarction induction, and. Cardioprotective effect of ritonavir, an antiviral drug, in. However, the effect of ritonavir on cardiac glut4 inhibition during myocardial necrosis is not investigated. Pretreatment with black cumin offered a protective effect against isoproterenol induced myocardial infarction in rats as evidenced by cardiac markers and lipid profile of the heart tissue. This model becomes relevant if we consider that increased adrenergic. Jan 11, 2020 our study is aimed at evaluating the effects of pretreatment with polylactic. Tacrolimus ameliorates functional disturbances and oxidative stress in isoproterenol induced myocardial infarction arash khorrami1,2, mojtaba hammami2, mehraveh garjani2, nasrin malekidizaji1 and alireza garjani1 abstract background.
Mar 20, 2009 abstract the present study evaluated cardioprotective effect of lyophilized hydroalcoholic extract of moringa oleifera in the isoproterenol isp induced model of myocardial infarction. While myocardial injury encompasses any type of acute myocardial damage such as necrosis induced by myocarditis, sepsis or endogenous catecholamines, mi is defined as ischemic damage resulting from an insufficient myocardial oxygen supply 1 2. Cardioprotective effect of squalene on lipid profile in. Acute treatment with metformin improves cardiac function. In the present study, we evaluated the role of ritonavir in isoproterenol induced. We have examined the protective effect of taurine on the myocardial antioxidant defense system in isoprenaline isoproterenol induced myocardial infarction in rats, an animal model of myocardial infarction in man. Luteolin7diglucuronide attenuates isoproterenolinduced. In fact, mi, an acute condition of necrosis of myocardium is the most lethal.
Myocardial infarction mi is an important cause of mortality around the world, resulting from an ischemic necrosis induced by a vascular occlusion. Protective effects of cardamom in isoproterenolinduced myocardial. Cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats. Sequential changes of energy metabolism and mitochondrial function in myocardial infarction induced by isoproterenol in rats. Tacrolimus ameliorates functional disturbances and oxidative. Pdf the effect of astragaloside iv on isoproterenolinduced. Forty albino rats divided into six groups of four rats each were used for the. Mi is the most clinically encountered ischemic heart diseases and remains. Apoptosis, inflammation, isoprenaline, myocardial infarction. Ginsenoside re is the main chemical component of panax ginseng. Isoproterenol injections alone caused the expected cardiotoxicity. Vasodilators may play positive role in myocardial infarction mi.
Guidelines of our institutional animal ethical committee iaec. Effects of curcumin nanoparticles in isoproterenolinduced. Myocardial infarction is usually induced in small animals by means of invasive techniques based on mechanical coronary obstruction. Myocardial infarction, lipid peroxidation, black cumin, cardiac markers myocardial infarction mi is a therapeutic. Shift in antioxidant parameters, lactate dehydrogenase ldh together with morphological and histopathological changes were investigated. Isoproterenol iso administration induced the myocardial injury as evidenced by. The effect of pretreatment with curcumin nanoparticles nc compared to conventional curcumin cs on blood pressure, electrocardiogram, and biological changes on isoproterenol iso induced myocardial. Moringa oleifera leaf extract prevents isoproterenolinduced. Cardio protective role of wogonin loaded nanoparticle against. Pdf evaluation of cardioprotective role of vinpocetine in. It was hypothesized that endurance exercise training would attenuate isoproterenolinduced myocardial necrosis in the rat by increasing the concentration of prostacyclin in the myocardial vasculature. Rats were randomly assigned to exercise and control groups. Cardioprotective potential of ocimum sanctum in isoproterenol. All national and international guidelines for the care and use of animals were closely followed.
Myocardial infarction induction with isoproterenol raised leukocytes and neutrophils counts, sgot, troponin i and urea concentrations, reduced catalase enzyme. Myocardial damage induced by a single high dose of. The inflammatory responses play a major role in the pathogenesis of acute myocardial infarction mi. Curcumin nanoparticles protect against isoproterenol induced. This study aimed to investigate the protective effect of ginsenoside re on isoproterenol induced myocardial injury in rats. Pdf the present study was designed to investigate the cardioprotective effects of sundarban honey sh in rats with isoproterenol iso induced. Thirty young, male, wistar rats 145 to 230 g were randomly allocated in two groups. Therefore, mi in animal models studies should be induced in conscious animals with intact reflexes for greater clinical re levance. This study aimed to investigate the protective effect of betaine on tissue structure and renal function after isoprenaline.
As it has been reported that isoproterenol can cause ischemic myocardial alterations, lipid peroxide generation and procoagulant activity, we administered it to rabbits in order to induce a noninvasive myocardial infarction associated with above mentioned. Based on the results presented, we conclude that the model of myocardial infarction induced by isoproterenol in rats was adequately reproduced and validated in our laboratory and caused increased mortality and myocardial injury markers ast and troponin i, reduction of catalase activity and levels of glutathione and histopathological changes. Preventive effect of agnucastoside c against isoproterenolinduced. Mechanism of isoproterenol induced myocardial damage. Role of nitric oxide in isoproterenolinduced myocardial.
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